CBD & Nanotechnology
WHAT IS CBD?
CBD (Cannabidiol) is one of the many exogenous cannabinoids synthesized from Cannabis and Hemp plants. Its popularity and usage have been exploding in the mainstream and more uses of CBD are being discovered every day. CBD works by activating an endogenous system in our bodies known as the endocannabinoid system (ECS). This system is comprised mostly of CB1 and CB2 receptor sites. CBD works by activating or inactivating these receptor sites. The ECS is like any other system in our body ie. lymphatic, endocrine etc. It regulates our mood, sensation of pain, and inflammation as well as immune function. Consuming CBD is thought to have a regulatory balancing effect on our ECS, and therefore can promote a general sense of well being and harmony.
Bioavailability is defined as “The proportion of a drug or other substance which enters the circulation when introduced into the body and so is able to have an active effect.” CBD is classified by the biopharmaceutical class system as a Type 2 drug which exhibits poor aqueous solubility and high permeability. One of the main disadvantages of such “drugs” is that they need careful formulation to avoid being degraded, metabolized, and cleared by the digestive system and first-pass metabolism (liver) before being absorbed. As many as 70% of drugs on the market today fall into this classification of exhibiting poor aqueous solubility.
The mainstream CBD industry focuses on oil-based delivery formulations, which are grossly archaic in the pharmaceutical and medical field. Many companies and consumers have never heard of bioavailability, and are unaware that up to 70% of the CBD they are taking is being cleared by the body before ever making it into the bloodstream. Infused by Epic products uses cutting edge and proprietary technology borrowed in parts from food and Pharma sectors to deliver industry best practices for enhanced drug delivery. The future of the CBD and wellness industry will be built on the platform of enhanced therapeutic delivery systems.
WHAT DOES NANO MEAN AND IS IT IMPORTANT?
Nano simply means that the particles are much smaller than particles delivered through a Micro, or Macro suspension. To put things into perspective, a human red blood cell is approximately 5,000 nanometers. Infused by Epic particles are under 50 nanometers, that’s 100x smaller. When the same amount of CBD is broken down to such a small particle size, the surface area increases exponentially. More surface area means more potential for bonding at the ECS receptor sites. Pretty simple common sense understanding. Nano emulsification is one method to make particles really small, and remain small while suspended in an aqueous (water) medium. The surface-active modifiers used in the formulation must be nontoxic, and able to achieve high shelf stability without creaming or sedimentation (separating), especially when dissolved in a beverage or infused in food.
Nanoemulsions offer customizable concentrates with active drug loading to meet the end products’ needs. An example of this would be Infused by Epic’s standard emulsion which is able to load 10mg of Nano CBD into 1 milliliter (ml) of water. This can be diluted into a beverage easily and uses a minimum of excipient ingredients.
In many cases, vitamins, antioxidants, and nutraceuticals aren’t highly bioavailable by nature, and drug loading must be high. Therefore, the body is tasked with processing those vital elements via the GI tract when consumed orally. Many times, these molecules aren’t absorbed, and instead, are excreted or retained in the body. One of the main problems with CBD and other cannabinoids is that they are lipophilic (fat-soluble). Our technology addresses this issue by ensuring that cannabinoids and other nutraceuticals are converted to a water-soluble “colloidal suspension”. These suspensions enhance the delivery of bioactive molecules and eliminate malabsorption. In addition, the reduction in particle size to submicron levels ~50 nanometers or less, allows easy passage through absorption sites, and facilitates access to the bloodstream across all delivery routes (oral, transdermal, sublingual, ocular, etc.)
WHAT ABOUT SOURCE MATERIALS?
Infused by Epic uses only the cleanest third-party tested CBD products in our emulsified formulations.
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